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Sickle cell disease is a genetic disease where the body produces abnormal crescent- or sickle-shaped red blood cells. These cells don't last as long as normal, round red blood cells, which leads to anaemia. The sickle-shaped cells also get stuck in blood vessels, blocking blood flow which can cause pain and organ damage.
Follow the links below to find information about sickle cell disease.
Reviewed February 2009
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| Title: |
Vaccines for preventing invasive salmonella infections in people with sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Salmonella organisms are probably second only to pneumococcus among bacterial causes of infection in people with sickle cell disease. Infection with these bacteria can lead to complications and reduce the quality of life of people with the disease and s...
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| Date: |
Aug 2009
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| Title: |
Antibiotics for treating osteomyelitis in people with sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Sickle cell disease affects millions of people throughout the world. Osteomyelitis, a bone infection, is one of the major complications. Antibiotics are given to treat it, but there is no worldwide standard treatment. We searched for randomised controll...
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| Date: |
Apr 2009
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| Title: |
Treatment for avascular necrosis of bone in people with sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
There is currently insufficient evidence, in the form of randomised controlled trials, to assess the beneficial and harmful effects of specific therapies for avascular necrosis of bone in people with sickle cell disease. High quality randomised controll...
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| Date: |
Mar 2009
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| Title: |
Hematopoietic stem cell transplantation for children with sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Sickle cell disease is a genetic disorder mainly characterized by the presence of deformed, sickle-shaped red blood cells in the blood stream. These cells deprive tissues of blood and oxygen resulting in periodic and recurrent painful attacks. Complicat...
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| Date: |
Nov 2008
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| Title: |
Hydroxyurea for sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Haemoglobin is the substance within the red blood cells that carries oxygen around the body. Sickle cell disease (SCD) is an inherited genetic disorder where there are problems with the haemoglobin. Crystals form in the red blood cells and block the blo...
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| Date: |
Nov 2008
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| Title: |
Antibiotics for treating acute chest syndrome in people with sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Sickle cell disease affects millions of people throughout the world. Acute chest syndrome is a major cause of illness and death in people with sickle cell disease. Symptoms include fever, chest pain and a raised white blood cell count. Acute infection o...
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| Date: |
Oct 2008
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| Title: |
Inhaled nitric oxide for acute chest syndrome in people with sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Sickle cell disease is an inherited blood disorder affecting approximately 250 million people worldwide. Sickle-shaped red blood cells which are characteristic of sickle cell disease may block blood vessels causing pain, tissue death and even severe dam...
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| Date: |
Oct 2008
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| Title: |
Piracetam for reducing the incidence of painful sickle cell disease crises
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Sickle cell disease is one of the most common genetic disorders and affects about 250 million people (5% of the world's population). It is characterised by sickle-shaped red blood cells which may block blood vessels. This can lead to pain and damage to ...
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| Date: |
Oct 2008
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| Title: |
Pneumococcal vaccines for sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
People with sickle cell disease are particularly prone to pneumococcal infection, which may be fatal. Children aged up to 23 months are at high risk, but usual polysaccharide pneumococcal vaccines may not work in this age group. New conjugate pneumococc...
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| Date: |
Sep 2008
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| Title: |
Treatments for priapism in boys and men with sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Priapism (the prolonged painful erection of the penis) is common in males with sickle cell disease (SCD). The length of time priapism lasts differs for different types and so does the medical treatment for it. Self-management approaches may be helpful. ...
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| Date: |
Sep 2008
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| Title: |
Neonatal screening for sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Sickle cell diseases are inherited and affect mainly people of African origin. The red blood cells are abnormally (sickle) shaped, which can lead to life-threatening complications. They are most likely to be fatal in the first few years of life since af...
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| Date: |
Aug 2008
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| Title: |
Blood transfusion for preventing stroke in people with sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
In sickle cell disease there are fewer red blood cells. This means less oxygen is carried to tissues and there are problems throughout the body. Sickled red blood cells can block blood vessels in the brain, leading to strokes. We aimed to compare long-t...
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| Date: |
Jul 2008
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| Title: |
Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Sickle cell disease is an inherited blood disorder. People with sickle cell disease often suffer from acute chest syndrome, although it is not known why. Acute chest syndrome can cause fever, coughing, chest pain and shortness of breath and can be life-...
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| Date: |
Jul 2008
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| Title: |
Sickle cell disease
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| Publisher: |
Virtual Medical Centre.com
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| Description: |
Information on the symptoms, treatment and diagnosis of Sickle cell anaemia by professional health specialists.
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| Date: |
Feb 2008
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| Title: |
Fluid replacement therapy for acute episodes of pain in people with sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Sickle cell disease is a common genetic disorder characterised by periodic episodes of pain which usually happen again and again throughout life. These episodes occur when sickled cells obstruct blood vessels. The degree of pain may range from a mild di...
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| Date: |
Jan 2008
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| Title: |
Preoperative blood transfusions for sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Once they have given up their oxygen, red blood cells in people with sickle cell disease become shaped like crescents. These cells can block blood vessels, which causes problems throughout the body. People with sickle cell disease often need surgery, bu...
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| Date: |
Aug 2007
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| Title: |
Drugs for preventing red blood cell dehydration in people with sickle cell disease
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| Publisher: |
John Wiley and Sons, Ltd. for The Cochrane Collaboration
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| Description: |
Sickle cell disease is an inherited condition that causes red blood cells to become sickle shaped when they lose water. This leads to a high risk of the blood vessels becoming blocked. Such blockages can cause pain, stroke and damage to organs. Recent t...
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| Date: |
Jul 2007
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